-
-
-
Steven A Vokes
Professor
Molecular BiosciencesUnderstanding how transcriptional repressors, especially underlying Hedgehog signaling, interface with chromatin to regulate developmentsvokes@austin.utexas.edu
Phone: 512-232-8359
Office Location
PAT
Postal Address
2415 SPEEDWAY
AUSTIN, TX 78712-
Dr. Vokes graduated from Swarthmore College with a Bachelor of Arts in Biology and received his doctoral degree in Molecular Biology from the University of Texas at Austin, examining the process of blood vessel formation during early embryonic development under the supervision of Dr. Paul Krieg. As a postdoctoral fellow at Harvard University, he studied developmental genetics and genomics in Dr. Andy McMahon's laboratory and was the recipient of Helen Hay Whitney and Charles A. King postdoctoral fellowships. He joined the faculty at UT Austin in 2008 and is currently an Associate Professor in the Department of Molecular Biosciences. His research, supported by the National Institute for Health, investigates how transcriptional repressors, especially those underlying Hedgehog signaling, interface with chromatin to regulate gene expression.
-
The Vokes lab investigates how transcriptional repressors, especially those underlying Hedgehog signaling, interface with chromatin to regulate gene expression. We study these responses during development, homeostasis and regeneration. Our experimental approach is centered on the mouse model system in a variety of contexts, including the developing limb, knee and larynx, where we employ a combination of genetic and genomic approaches.
-
Representative Publications:
Ramachandran,, J., Zhou, W., Bardenhagen,, A.E., Nasr, T., Zorn, A.M., Ji, H. and Vokes, S.A. (2022). Hedgehog regulation of epithelial cell state and morphogenesis in the larynx. eLife 11:e77055.
Lex, R.K. and Vokes, S.A. Timing is everything: transcriptional repression is not the default mode for regulating Hedgehog signaling. BioEssays 44:e2200139.
Lex, R.K., Zhou, W., Ji, Z., Falkenstein, K.N., Schuler, K.E., Windsor, K.E., Kim, J.D., Ji, H. and Vokes, S.A. (2022). GLI transcriptional repression is inert prior to Hedgehog pathway activation. Nature Communications 13:808.
Lex, R.K., Ji, Z., Falkenstein, K.N., Zhou, W., Henry, J.L., Ji, H. and Vokes, S.A. (2020). GLI transcriptional repression regulates tissue-specific enhancer activity in response to Hedgehog signaling. eLife 9:e50670.
Ramachandran, J., Liu, Z., Gray, R.S. and Vokes, S.A. (2019). PRMT5 is necessary to form distinct cartilage identities in the knee and long bone. Developmental Biology pii: S0012-1606(19)30376-8.
Norrie, J.L., Li, Q., Co, S., Huang, B., Ding, D., Uy, J.C., Ji, Z., Mackem, S., Bedford, M.T., Galli, A., Ji, H. and Vokes, S.A. (2016). PRMT5 is essential for the maintenance of chondrogenic progenitor cells in the limb bud. Development 143:4608-4619.
-
Human Genetics (BIO 325T)
-
