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Belardi, Brian

Brian Belardi

Assistant Professor
McKetta Department of Chemical Engineering

Lyondell Chemical Company Endowed Faculty Fellowship in Engineering (Holder)

Synthetic Biology, Chemical Biology, and Biophysics of Biological Barriers


Office Location

Postal Address
AUSTIN, TX 78712

B.S. Carnegie Mellon University (2008)

Ph.D. University of California, Berkeley (2014)

Research Interests

My lab focuses on probing, perturbing, and re-programming biological barriers across length scales. Metazoans - which include humans - have evolved to assemble exquisite semi-permeable membrane structures that regulate the flux of select material in and between cells and tissues. The complex, multi-component topologies and mesh-like architectures of biological barriers are rich sources of biological information and often deteriorate in pathological conditions. We study epithelial cells and tissue, extracellular matrix, and cell membrane interfaces to gain a quantitative and mechanistic understanding of these barriers. Leveraging these fundamental insights, researchers in my lab design smarter molecules, materials, and cells for improving drug bioavailability in the gut and brain, detecting and repairing cancerous tissue, and for regenerative medicine applications.